question on IgA glomerulopathy (FA 2010 vs RR 3rd ed) - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
USMLE Articles
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam

Thread Tools Search this Thread Display Modes
Old 09-08-2010
USMLE Forums Newbie
Steps History: Not yet
Posts: 1
Threads: 1
Thanked 0 Times in 0 Posts
Reputation: 10
Kidney question on IgA glomerulopathy (FA 2010 vs RR 3rd ed)

Hey guys, I was reading up on Nephritic Glomerular dz's in Rapid Review path and for IgA glomerulopathy (Berger's dz) i noticed it says its due to: "Increased mucosal synthesis and DECREASED CLEARANCE OF IgA; INCREASED SERUM IgA"

when I looked up IgA glomerulopathy in First Aid 2010, it's says its due to "INCREASED SYNTHESIS OF IgA"

... i'm confused... is IgA synthesis increased b/c the IgA is getting trapped in the mesangial cells of the kidney which are then being destroyed by anti-bodies, hence decreased clearance????
Reply With Quote Quick reply to this message

Old 09-08-2010
Ex-USMLE Forums Staff
Steps History: 1+CK+CS+3
Posts: 753
Threads: 106
Thanked 2,284 Times in 470 Posts
Reputation: 2332
Arrow Neither Nor

The pathophysiology of Berger disease is not yet completely understood. Statistics has shown that over 50% of the patients have elevated IgA levels but could not be attributed to causation because the reverse is not true, i.e. not all persons with high IgA levels (e.g. AIDS patients) will develop IgA nephropathy.

So neither increased synthesis nor decreased clearance should be construed as a principle concept in the pathophysiology and you are not going to be asked about it in the USMLE Exam.

Reply With Quote Quick reply to this message
The above post was thanked by:
donofitaly (09-09-2010), dr z (10-30-2010)


Pathology-, Renal-

Quick Reply

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Please enter a password for your user account. Note that passwords are case-sensitive.
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Where you live. Leave blank if you don't want to tell.


Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Similar Threads
Thread Thread Starter Forum Replies Last Post
2010 Kaplan CenterPrep & 2010 Pass Program Video Lectures kingoftheboards USMLE Links & Free Ads 5 03-28-2011 06:44 PM
3rd LOR will be late rsoody IMG Residency Match Forum 3 08-25-2010 05:07 PM
runner with pain between 3rd n 4th metatarsal bones Seetal USMLE Step 1 Forum 3 08-17-2010 05:15 AM
IgA Protease Microorganisms Mnemonic step1an USMLE Step 1 Mnemonics 0 07-31-2010 12:59 PM
Goljan RR 3rd edition... khushboo USMLE Step 1 Forum 8 06-22-2010 11:07 PM

Find Us on Facebook
Powered by vBulletin® Version 3.8.8
Copyright ©2000 - 2020, vBulletin Solutions, Inc.
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2020 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2019)