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Old 01-13-2013
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Default minimal change disease

Can't solve alone..

The proteinuria of MCD is selective, because of a decrease in the normal content of polyanion in the basement membrane.
In this part, not really understandable how the subsequent loss of negative charge may follow. (Largely albumin alone is lost.)

Could anyone help?
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Old 01-14-2013
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MCD which is the most common cause of nephrotic syndrome in children results from inappropriate immune activation that causes T cell activation & thereby releasing T-cell cytokines which leads to loss of polyanion i.e. negative charge of the GBM. As GBM loses it's negative charge so thereby it can't repulse the albumin which is also negatively charged. Consequently Selective Proteinuria occurs.
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