Tay Sachs and Niemann Pick
How to tell them apart?
They both common in Ashkenazi Jews
They both cause Cherry red spot
They both cause blindness
They both kill early in life
They both cause mental retardation
They both cause seizures
They both are autosomal recessive
They both are lysosomal storage disorders
Nieman pick has reticuloendothelial system involvement
No Nieman pick child comes to the hospital without huge liver and spleen
Also in Nieman pick you have the cytoplasmic vacuolation and the bone marrow involvement
All these are not seen in Tay Sach
OK but then we'll mix up Nieman with Gaucher, again seen in Ashkenazi Jews!
The other types of Gaucher (the infantile and the juvenile) are as killing as Niemman but they are not seen in Ashkenazi Jews
In any case Gaucher does not affect the eyes with cherry red spots
some more differences
Tac sachs has no hepatospleenomagaly,
lysosome with onion skin , mostly in jews of eastern europeon descent
NiemnnPick has hepatospleenomagaly,
zebra body inclusion and cytoplasmic vacolization (foam cells) present :)
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