Pathophysiology of ascites in Hepatitis C infection - USMLE Forums
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Old 09-27-2010
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Liver Pathophysiology of ascites in Hepatitis C infection

A pt positive for hep c now developed Ascites what is the physiology ??

a. inc. hydrostatic pressure
b. decrease oncotic pressure
c. both
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Old 09-27-2010
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When Hepatitis c leads to cirrhosis it increases hydrostatic pressure in portal vein. This leads to increased hydrostatic pressure in all superior mesenteric, inferior mesenteric, splenic and splenic veins, resulting decreased drainage and edema in all areas drained by these veins and thus leading to ascitis. However, ascitis also results from decreased oncotic pressure caused by liver malfunction as the liver synthesizes the plasma proteins.

So the answer is that both increased hydrostatic pressure and decreased oncotic pressure contributes to ascites in case of cirrhosis, which can be caused by hepatatitis c.
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Gastrointestinal-Tract-, Pathology-

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