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dr z 11-16-2010 06:30 AM

ALA Dehydratase or ALA Synthase
In firstaid 2010 page 348:
lead poisoning enzyme affected is "ALA dehydratase"
In errata FA (from firstaid website) it says replace it with " ALA synthase "
which one is correct plz clarify , thanks

usmle0987 11-16-2010 06:44 AM

Lead denatures Ferrochelatase (Heme synthase), ALA Dehydrase and Ribonuclease.

hedihav_x 11-16-2010 06:48 AM

lead poisoning inhibits ALA dehydrase & ferrochelatase in heme synthesis.
vit B6 deficiency effects on ALA synthase...

StepTaker 11-16-2010 08:52 AM

The hemoglobin pathway has been excellently demonstrated with cilinical correlation by our staff Sabio here's the link

Haisook 11-16-2010 09:30 AM

Lead poisoning directly inhibits ALA dehydratase and ferrochelatase. Lead poisoning can cause sideroblastic anemia which inhibits ALA synthase.

So in short, lead poisoning inhibits ALA dehydratase directly and ALA synthase indirectly.

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