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Old 08-25-2013
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Default Huntington Question


quick question:

Atrophy of striatal nuclei, esp. caudate nucleus.

Don't the indirect (supression) and direct (driving) pathway of the basalganglia start with the Striatum

direct: Striatum -> Globus Pallidus internal segment ....
indirect: Striatum -> Globus Pallidus external segment -> subthalamic nucleus -> Globus pallidus internal segment

so if I destroy the Striatum, how can the direct way still work and not the indirect, and I have a drive of movement?

and FA says Striatum= Putamen (motor) + caudate (cognitive).

In Glutamate toxicity in Huntington do both parts of the Striatum get destroyed, cause Kaplan was talking about the head of the caudate nucleus only... so this would explain the conignitive dysfunction in Huntington.

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