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-   -   ACE Inhibitors effects on Aldosterone Renin and Bradykinin (https://www.usmle-forums.com/usmle-step-1-forum/4999-ace-inhibitors-effects-aldosterone-renin-bradykinin.html)

mtoi 11-21-2010 07:16 PM

ACE Inhibitors effects on Aldosterone Renin and Bradykinin
 
explain the effect [decrease/ increase/ no change] of angiotensin-converting-enzyme inhibitor on aldosterone, renin and bradykinin

hedihav_x 11-21-2010 09:12 PM

ACEIs will decrease aldosterone,increase renin & increase bradykinin

mtoi 11-22-2010 03:54 AM

perfect
i understand decrease in aldo and increase in bradykinin, but not increase in renin. please explain

decrease in aldo is therapeutic effect for decreasing blood pressure
increase in bradykinin is side effect causing cough and angioedema

step1an 11-22-2010 08:52 AM

Quote:

Originally Posted by mtoi (Post 20587)
perfect
i understand decrease in aldo and increase in bradykinin, but not increase in renin. please explain

decrease in aldo is therapeutic effect for decreasing blood pressure
increase in bradykinin is side effect causing cough and angioedema

Just for recap...

Renin is released from kidney in response to
  • sympathetic stimulation(via β1-receptors)
  • renal artery hypotension
  • decreased sodium delivery to the distal tubules of the kidney.
Renin is a proteolytic enzyme which converts circulating angiotensinogen to Angiotensin 1, which is converted by ACE to Angiotensin 2.

So, by blocking ACE..... the level of Renin, Angiotensin 1 & Bradykinin should increase and the level of Angiotensin 2 & Aldosterone should fall.

hardik221186 11-22-2010 06:27 PM

Renin is released from kidney in response to
sympathetic stimulation(via β1-receptors)
renal artery hypotension
decreased sodium delivery to the distal tubules of the kidney.
Renin is a proteolytic enzyme which converts circulating angiotensinogen to Angiotensin 1, which is converted by ACE to Angiotensin 2.

So, by blocking ACE..... the level of Renin, Angiotensin 1 & Bradykinin should increase and the level of Angiotensin 2 & Aldosterone should fall.

and also loss of negative feedback of angiotensin 2 on AT receptor located on kidney. so increase in renin and angiotensin 1.


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