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Old 10-04-2009
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Question Hageman Factor Deficiency?

One question is saying it causes hemorrhage and another is saying it causes thrombosis?

What is the correct answer

Any help plz
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Emorydoc (09-21-2013), rigbbm (01-07-2019), Usmle16Forall (09-06-2017)

Old 10-04-2009
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there's a big mystery about factor XII

because being on the top of the intrinsic pathway one should expect real hemorrhagic tendency when it's deficient, however the most common clinical presentation is simple incidental high PTT

but it is also plasminogen activator therefore it's needed to dissolve the clot and it's deficiency has been proposed as a cause of thrombosis

I think the latter effect is more loved by USMLE question makers

So you pick thrombosis
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Emorydoc (09-21-2013), nskpitafi (06-30-2015), rigbbm (01-07-2019), Usmle16Forall (09-06-2017)



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