Chronic glucocorticoid treatment - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
USMLE Articles
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam

Thread Tools Search this Thread Display Modes
Old 11-24-2013
medicalbiology's Avatar
USMLE Forums Guru
Steps History: Not yet
Posts: 394
Threads: 128
Thanked 116 Times in 94 Posts
Reputation: 126
Drug Chronic glucocorticoid treatment

In uworld it is written that prednisolone chronic treatment decrease CRH, ACTH and also cortisol.
BUT why cortisol is decresing it should be increase as we are giving exogenous cortisol(i.e prednisolone)
Reply With Quote Quick reply to this message

Old 11-24-2013
Neuron's Avatar
USMLE Forums Addict
Steps History: 1+CK+CS+3
Posts: 184
Threads: 5
Thanked 87 Times in 63 Posts
Reputation: 97

I remember the qs. It is quite different because it talks about a pt under prednisolone that is doing a surgical procedure.

We know that in particular situation such as stress, surgical procedure, infection and so on there is an increase in cortisol release (endogenous). However the pt is under steroid so he can not have a normal cortisol stress-related release (the exogenous steroid inhibits via negative feedback both the hypothalamus and the pituitary) thus compared to a normal subject this pt will have a decrease in crh, acth and cortisol.

By the way during infection or surgical procedures, the steroid dosage in a pt under chronic trt should be increased to prevent this kind of situation.
Reply With Quote Quick reply to this message


Endocrine-, Pharmacology-, Physiology-

Quick Reply

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Please enter a password for your user account. Note that passwords are case-sensitive.
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Where you live. Leave blank if you don't want to tell.


Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Similar Threads
Thread Thread Starter Forum Replies Last Post
Treatment for hepatitis b & c ..(acute and chronic)) dr.dhruvdesai USMLE Step 2 CK Forum 2 05-31-2013 09:32 PM
chronic treatment of gout...what is the best initial regimen? tyagee USMLE Step 2 CK Forum 8 05-28-2012 11:01 PM
Glucocorticoid Increase Protein Synthesis! avash.nrs USMLE Step 1 Forum 0 03-29-2012 07:44 PM
Chronic treatment side effects drnrpatel USMLE Step 2 CK Forum 7 12-08-2011 07:03 PM
glucocorticoid - anticancer MOA schiwei USMLE Step 1 Forum 4 12-15-2010 10:15 PM

Find Us on Facebook
Powered by vBulletin® Version 3.8.8
Copyright ©2000 - 2020, vBulletin Solutions, Inc.
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2020 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2019)