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-   -   Can you guess which virus? (https://www.usmle-forums.com/usmle-step-1-forum/5323-can-you-guess-virus.html)

aktorque 12-10-2010 09:11 PM

Can you guess which virus?
 
A 19-year-old white male presents to the infirmary complaining of pharyngitis, rhinorrhea, and intermittent wheezing. Pertinent social history includes enlistment in the U.S. Army two months ago, and the patient is currently stationed at Fort Bragg, North Carolina. A physical exam reveals injected conjunctivae bilaterally and diffuse wheezing bilaterally on pulmonary auscultation. Positive cold agglutinin reaction is noted. A virus is isolated in cell culture, and further evaluation reveals a non-enveloped virus with double-stranded linear DNA. Which of the following statements is correct, concerning this viral infection and neoplasia?

A This viral infection is linked to Burkitt's lymphoma
B This viral infection can cause progressive multifocal leukoencephalopathy.
C This viral infection is linked to hepatocellular carcinoma.
D This viral infection is linked to histiocytoma.
E Infection by certain serotypes may cause sarcoma.
F This viral infection is linked to nasopharyngeal carcinoma.

i_m_possible 12-10-2010 10:33 PM

it seems like adeno virus infection,,,

pt is workin for army,signs of conjunctivitis and resp. distress,,,

but i don know any neoplasia caused by adeno,,
i guess the best answer is B,,,,PML caused by polyoma virus naked dsdna virus(but then question says linear dna ,polyoma and papilloma are circular):rolleyes:
the only dsdna naked viruses are parvo,papova,adeno

drahmednawaz 12-11-2010 02:40 AM

answer is adenovirus.

Adenoviruses are nonenveloped viruses with double-stranded linear DNA and an icosahedral nucleocapsid. They are the only viruses with a fiber protruding from each of the 12 vertices of the capsid. The fiber is the organ of attachment and is a hemagglutinin. When purified free of virions, the fiber is toxic to human cells.

There are 41 known antigenic types; the fiber protein is the main type-specific antigen. All adenoviruses have a common group-specific antigen located on the hexon protein.

Certain serotypes of human adenoviruses (especially 12, 18, and 31) cause sarcomas at the site of injection in laboratory rodents such as newborn hamsters. There is no evidence that adenoviruses cause tumors in humans

aktorque 12-11-2010 08:27 AM

Quote:

Originally Posted by drahmednawaz (Post 22041)
answer is adenovirus.

Adenoviruses are nonenveloped viruses with double-stranded linear DNA and an icosahedral nucleocapsid. They are the only viruses with a fiber protruding from each of the 12 vertices of the capsid. The fiber is the organ of attachment and is a hemagglutinin. When purified free of virions, the fiber is toxic to human cells.

There are 41 known antigenic types; the fiber protein is the main type-specific antigen. All adenoviruses have a common group-specific antigen located on the hexon protein.

Certain serotypes of human adenoviruses (especially 12, 18, and 31) cause sarcomas at the site of injection in laboratory rodents such as newborn hamsters. There is no evidence that adenoviruses cause tumors in humans

OMG.... You have given a genius explanation for this qn. Thank you so much. The answer is E) Infection by certain serotypes may cause sarcoma. As you said that Adenoviruses do not cause tumors but in recent study said that their certain serotypes can cause malignant in human (ex: sarcomas).


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