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cordoba 10-30-2009 04:17 PM

Tricky Question; Drug causing this baby problem
 
A pregnant female did ultrasound and it was reported as the baby is having a fluid sac on the lower back. What medication could exacerbate the dietary deficiency responsible for the this defect?

a- Carbamazepine
b- Co trimaxazole
c- Lithium
d- Valproic Acid
e- Captopril

Ok guys let's see who'll get the question right :rolleyes:

smile135 10-30-2009 05:54 PM

Quote:

Originally Posted by cordoba (Post 2381)
A pregnant female did ultrasound and it was reported as the baby is having a fluid sac on the lower back. What medication could exacerbate the dietary deficiency responsible for the this defect?

a- Carbamazepine
b- Co trimaxazole
c- Lithium
d- Valproic Acid
e- Captopril

Ok guys let's see who'll get the question right :rolleyes:

I think it is NTD caused by folate deficiency..
From interfering the dietary folate absorption and associated with NTD , most likely the drug will be anticonvulsant...
So i chose valproic acid as it is a teratogenic anticonvulsant causing NTD

cordoba 10-30-2009 06:07 PM

Quote:

Originally Posted by smile135 (Post 2383)
I think it is NTD caused by folate deficiency..
From interfering the dietary folate absorption and associated with NTD , most likely the drug will be anticonvulsant...
So i chose valproic acid as it is a teratogenic anticonvulsant causing NTD

Correct!

How did you know that!

Why not co trimaxazole, isn't it anti folate?
Why not carbmazepine, it also causes spina bifida?

JSA-mant 10-30-2009 07:14 PM

Quote:

Originally Posted by cordoba (Post 2384)
Why not co trimaxazole, isn't it anti folate?

Sulfonamides inhibit folate synthesis in bacteria not humans
human do not make folate

smile135 10-30-2009 10:54 PM

Quote:

Originally Posted by cordoba (Post 2384)
Correct!

How did you know that!

Why not co trimaxazole, isn't it anti folate?
Why not carbmazepine, it also causes spina bifida?


For cotrimazole. it inhibits folate syn: in bacteria and not in human ...
for carbamazepine, it stays 2nd compared to valproic acid although there is association with NTD.

afridi123 05-09-2013 01:37 PM

valpraoic acid and phenytoin inhibit the intestinal conjugases which are responisble for folic acid absorption


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