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Old 11-16-2009
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Virus Viral peptides on MHC class II

I've seen a question answered by telling me that viral peptide can be loaded on MHC II on APC! how is that possible?
I understand that viral peptides should be presented by class I (the endogenous pathway).

Anybody knows about that?

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Old 11-16-2009
YoramFishke's Avatar
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If the Antigen Presenting Cell has engulfed a cell that was previously infected with a virus, then yes it will present the viral peptides onto its MHC II molecule. But remember this peptide will not be recognized by CD8 but rather by CD4. The T helper will then decide what to do, like going in the TH1 or TH2 arms of the immune cascade.
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hunath (11-16-2009), Kaus (02-24-2018), Rookie (03-20-2012), sausan (11-16-2009)


Immunology-, Microbiology-

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