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Old 08-17-2012
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ObGyn maternal hypothyroidism

Hi all:

Kaptest says that maternal hypothyroidism has little effect on the fetus because the fetus produces his/her own thyroid hormone.

And I also check KLN OB/ GYN p. 88 it says that if pregnancy continues, the infant in healthy.

So if it is isolated maternal hypothyroidism, then baby is ok??

i also found this article:

Isolated maternal hypothyroidism: Overt maternal hypothyroidism typically is not a significant cause of fetal disease because it usually is associated with infertility. When pregnancy does occur, there is increased risk of intrauterine fetal death and gestational hypertension. Subclincial hypothyroidism is increasingly being recognized as a cause of developmental disease - this is a rather scary situation. Several investigators have found that mild maternal hypothyroidism, diagnosed only retrospectively from banked serum, may adversely affect the fetus, leading in children to such effects as slightly lower performance on IQ tests and difficulties with schoolwork. The most common cause of subclinical hypothyroidism is autoimmune disease, and it is known that anti-thyroid antibodies cross the human placenta. Thus, the cause of this disorder may be a passive immune attack on the fetal thyroid gland.
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Old 08-17-2012
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It depends on what is the etiology of hypothyroidism in the mother, for instance, if it is due to Hashimoto's i.e. auto immune, then the antibodies directed towards the mother's thyroid (which are IgG BTW) are able to cross the placenta and cause hypothyroidism in newborns. This would not be the case in a C/O hypothyroidism d/t say riedel's thyroidits or a C/O DeQuiveran's that does not recover (RARE!)
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ObGyn-, Pediatrics-

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