how about questions, are you getting any done along with the videos?
I'm on day 10 and i just cant do any questions along with the vids!

 

scored 69% on my UW block today!

swag swag

 

That's great!! Happy-2 Looks like all the hard work with DIT is paying off!

 

my scores in UW have also risen

i just dont get how this guy does it! i mean all he's doing is reading to us from a book! and still, every couple of days i feel like im on a higher level than i was before!

 

because when u actually use ur hand write the answers to questions.. U must reach the point where u say to urself... "looks like somebody hasnt been studying with his heart, thinks he's studying for a medical school exam where i can just memorize the last three letters of that drugs name and then i'll be able to answer the MCQ on the test''.. But not for step1 baby
Only hard work will pay off, my advice is study with full conscience and no cheating, after finishing three videos study the material like if the test was tomorrow... Even if takes 40 days, not just 21, its more important than solving questions.. Coz u only have to do this once, do it good,,,, and after that, a full thorough read of FA can be done in less than a week if the DIT course is given its right dedication and detirmination

 

What do you mean by " only hard work will pay off, study with full conscience, no cheating , i can just memorize the last three letters of that drugs name and then i'll be able to answer the MCQ on the test''.. But not for step1 baby " .
How do know all these people are not working hard, not studying with full conscience, and are cheating ( btw cheating who?). Some of us are studying for 10-14 hours /day, and revising everything at the end of 3 lectures- I don't know if you heard dr.jenkins right, he says to solve qs along with his course, thats why all these people are applying their knowledge and raising their scores, nothing wrong with it..... then why are you saying..."Even if takes 40 days, not just 21, its more important than solving questions.. "

BTW, didn't you couple of days ago post this "

im starting day 3, video #2 now
tomorrow [friday and saturday] is my weekend, im tearing that thing apart, hope to do days 3 [4,5,6] during the weekend, and finish day#3 today
You are advising us to do it in 40 days yet you want to do 3 days lectures in 2 days.

We all are trying to do our best in our own way, so please be kind not to negatively put others effots down. Thank you.

 

Finished 1st vid of day 9....I had to run an errand.

@rennaisance...I am doing 15-25 qs UW every day .And the in quizzes he gives after the end of the day, I score 99% every time...I think thats his key. If we listen to his lecture keenly( its audio-visual), its sits in brain better than when we study by ourselves + the Right brain bonusses little skits are great + the quizzes re-inforce the material. I can't wait to do some NBMEs after I finish this course.

@Dr.nick...u went from 65 to 69% in less than a week...amazing & your steady increase is awesome...keep it up.

@Hopetopass...Iam enjoying the course & am sure you will too... but at some points it gets tedious...just have to keep going.

alright, starting day 9 vid 2.

 

Finished day 9 vid 2....hormones...lot of concepts, I am going back & revising vid 1 & 2...its going to take some time...worth it for later.

 

Still doing 3rd vid of the day 9.....hate molecular biochem...going to be a long night...need a break now.

 

Done with day 9 videos. GN......tomorrow reproductive system which I recently studied so should go faster, vid 3 is genetics...which I am very poor at & studied long time ago. Off to bed.

 

Good morning. Starting day 10 vid 1...almost 2 hrs lecture.

 

done w/ vid 1 of the day. female repro tumors & drugs need revision again at the end of the day. Break time.

 

doing 2nd video, have gym & yoga on tuesday at 6 pm ugh...1.5 hr will be gone...need to compensate in the night.

 

day10 vid3
im really disapointed with how he covered the lysosomal storage diseases, he didnt review the text at all, just threw us into a quiz of it and then moved on.
first time in 10 days that i am disapointed in DIT.

 

@nick...I'll be starting 3rd video in half hr after dinner, just came back from gym, so wow...he didnt cover lysosomal dz well huh. Oh well, some of the topics, he does run through.

 

done with day 10 vids. He brushed through many parts of genetics, had to read thru kaplan LN (which I read long time ago) to understand concepts.
He explained gel electrophoresis well, & yeah lysosomal storage dz- he didn't even read a word from FA...directly went to quiz, but he said it is not HY ( which I didnt expect)...saves me a lot of trouble...I remember spending a lot of time studying it...practising the enzymes & products pathway, now I'm going to brush thru the main differentiating points. Exhausted..I have been hanging with these books for 14 hrs now....time to call it a night. GN

 

GM, starting day 11, vid 1...Male Repro & toxicology.

 

Anti-Androgens:
Finasteride- rx of BPH, male pattern balding
Flutamide- only in rx of prostrate cancer.
Ketoconazole & Spironolactone-
- used in rx of PCOS to prevent hirsutism.
- They have SEs of Amenorrhea & gynaecomastia---why? is it b'coz of dec testosterone---> inc estrogen?

 

Ketoconazole & Spironolactone-
- used in rx of PCOS to prevent hirsutism.
- They have SEs of Amenorrhea & gynaecomastia---why? is it b'coz of dec testosterone---> inc estrogen?

they block androgens (test and estrogen) at their receptors so they cant perform their actions
estrogen cant perform its action on the endometrium, so amenorrhea
testosterone not performing its action in men = gyno

 

There went my 1 hour....my mom called & I ended up spending 1 hr on phone.I still have to finish 1st lecture of the day..ugh.

 

@nick..I didn't see your explanation before, thanks....makes sense. may be I missed it, where did it say they act on receptors, I dint know that, only knew that they inhibit steroid synthesis & binding.
How is your prep coming along.

 

prep is ok
starting day11vid1 now
scored 60% in UW today, not great but still in the 60s, which is where i want to consistently be right now.

 

When is everyone planning on giving the step???

 

@pathophysio1..... my plan is to take by june 5th...hopefully will be ready & not postpone it.

@nick....60s consistently is very good...in next few weeks, maybe u'll jump to 70s....GL. I am planning to subscribe(2nd time) to UW as soon as I finish DIT ( 4-5 more days) and will start doing UW + nbmes + FA revision.

On to 2nd vid of the day.

 

yea im hoping to take it june 6th
just waiting for my ecfmg stuff to come back so i can book the date before its gone.

 

wow...we are in the same boat...but i think you are more prepared than iam.

 

quick test: whats the disease associated with cyclin D guys ?

 

oh man its one of those translocations, umm Burkitts? chr8 = bcl-1 = cyclin D?

or was it bcr = cyclin D?

eek.

Burkitts lymphoma. my final guess (off the dome).

 

****, bcl-1 is in mantle, not burkitts

so the answer is Mantle cell lymphoma? (had to check FA to see where bcl-1 is but i do recall from kaplan bcl-1 is linked to cyclin D... i think lol)

 

Yup, The answer is Mantle cell lymphoma; t(11:14). Chr 11 has bcl-1 (Cyclin D) which gets translocated to Chr 14 (IgG heavy chain - which is always active)...This results in Cyclin D hyperactivity

In Burkitts, its t(14:18) where Chr 18 is bcl-2 which gets translocated to Chr 14 (IgG heavy chain) and leads to bcl-2 activation which then inhibits apoptosis by blocking the bax channel.

Whats the mechanism of Cyclin D? Its an oncogene that phosphrylates RB gene leading to its activation which causes cells to move from G1 to S phase?

 

In Burkitts, its t(14:18) where Chr 18 is bcl-2 which gets translocated to Chr 14 (IgG heavy chain) and leads to bcl-2 activation which then inhibits apoptosis by blocking the bax channel.

burkitts is 8:14, no? c-myc activation? which is increased transcription?

the mechanism you described is follicular lymphoma if i recall correctly, in which its 14:18 translocation that results in bcl-2 overactivity and hence apoptosis inhibition (since cytochrome c cannot leave mitochondria). i dont think it affects BAX.

 

And sorry, I didn't mean to take this thread out of its context of DIT !! I was just testing hehe Happy-2

 

No worries, the q is in context to todays lecture...the Cyclins stuff was not clearly explained by dr.jenkins & the DIT notes given were too intense, so i was doing my own little research.Thanks for stretching our brains.