Hi everyone,
Just wanted to wrap my head around this concept. Basically, these 2 are in equilibrium with each other. If this balance is disrupted, then one goes down and the other takes over?
For example, if you give an antipsychotic that blocks Dopamine, then Acetylcholine is unopposed. From this you can get Neuroleptic Malignant Syndrome. The treatment for NMS is Dantrolene - which blocks Ach.
However, the other side effect of antipsychotics is Extra Pyramidal Symptoms. And the treatment of EPS is also an Anti Ach drug.
So are both EPS and NMS related to too much Ach/not enough Dopamine? Are both of these disorders caused by an unopposed Ach? Are they both on the same spectrum with EPS and NMS being etiologically related?
Finally, what about schizophrenia? Parkinsons is a problem of not enough Dopamine, whereas for Schizophrenia the treatment is to BLOCK dopamine. Does this mean that too much Dopa = Schizo, while too little Dopa = Parkinsons? And with Schizophrenia, if there is still a DA/Ach balance, will Schizophrenia have too little Ach?
Just wanted to wrap my head around this concept. Basically, these 2 are in equilibrium with each other. If this balance is disrupted, then one goes down and the other takes over?
For example, if you give an antipsychotic that blocks Dopamine, then Acetylcholine is unopposed. From this you can get Neuroleptic Malignant Syndrome. The treatment for NMS is Dantrolene - which blocks Ach.
However, the other side effect of antipsychotics is Extra Pyramidal Symptoms. And the treatment of EPS is also an Anti Ach drug.
So are both EPS and NMS related to too much Ach/not enough Dopamine? Are both of these disorders caused by an unopposed Ach? Are they both on the same spectrum with EPS and NMS being etiologically related?
Finally, what about schizophrenia? Parkinsons is a problem of not enough Dopamine, whereas for Schizophrenia the treatment is to BLOCK dopamine. Does this mean that too much Dopa = Schizo, while too little Dopa = Parkinsons? And with Schizophrenia, if there is still a DA/Ach balance, will Schizophrenia have too little Ach?