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mucopolysaccharidosis Type II & genetics

2.8K views 5 replies 5 participants last post by  bebix  
#1 ·
Hunter syndrome, or mucopolysaccharidosis Type II, is a rare disease that it shows X-linked recessive inheritance. In a female with 2 brothers with the diasese, which of the following is correct?

a) The probability that she is a carrier is 2/3.
b) If she is a carrier then the probability that each of her sons will be affected is 1 in 4.
c) If she is a carrier then the probability that each of her daughters will be a carrier is 1 in 4.
d) Before any carrier testing is carried out the woman can be correctly informed that the probability that her first son will be affected is 1 in 4.
 
#5 ·
a) The probability that she is a carrier is 2/3.---should be 1/2
b) If she is a carrier then the probability that each of her sons will be affected is 1 in 4.---if she's a carrier, Xx, then son will be 1/2 chance to have dz
c) If she is a carrier then the probability that each of her daughters will be a carrier is 1 in 4.--daughter would be 1/2 carrier
d) Before any carrier testing is carried out the woman can be correctly informed that the probability that her first son will be affected is 1 in 4.--this one is right. possibility to be a carrier 1/2, transfer the bad one to don is 1/2, so 1/2*1/2=1/4